Objective To investigate the effect of a mirabilite and rhubarb mixture on preventing mannitol-induced chemical phlebitis through animal experiments, and to provide a reference for clinical practice.
Methods Seventy-two healthy Japanese white rabbits from the same litter were selected and randomly divided into six groups, with 12 in each group.Except for the control group, chemical phlebitis was induced in the auricular vein of the rabbits in the other five groups by intravenous infusion of 20% mannitol solution.Starting from the first administration of the modeling, the 4∶1, 2∶1, and 1∶1 mixture groups received topical application of the mirabilite and rhubarb mixture at ratios of 4∶1, 2∶1, and 1∶1, respectively, at the modeling site.The Hirudoid group received topical Hirudoid cream, and the model group received wet dressing with normal saline.Each application lasted for 6 hours and was performed once daily.The control group received no treatment.Specimens were collected for pathological observation when the intravenous catheter indwelled for 72 h.
Results Statistically significant differences were observed among the six groups in terms of inflammatory cell counts, degree of venous endothelial detachment, perivenous edema, and intravascular thrombosis (all P＜0.05), with the control group, the Hirudoid group, and the three mixture groups showing significantly better outcomes than the model group.Furthermore, the 1∶1 mixture group demonstrated superior effects compared to the Hirudoid group, the 4∶1 mixture group, and the 2∶1 mixture group (all P＜0.05).
Conclusion The mirabilite and rhubarb mixture is effective in preventing mannitol-induced chemical phlebitis, with the 1∶1 ratio mixture showing the most pronounced effect.
